A review on biomaterials for ovarian tissue engineering

Considerable challenges in engineering the female reproductive tissue are follicle's unique architecture, need to recapitulate extracellular matrix, and vascularization. Over years, various strategies have been developed for preserving fertility women diagnosed with cancer, such as embryo, oocyte, or ovarian cryopreservation. While autotransplantation of cryopreserved is a viable choice restore prepubertal girls who begin chemo- radiotherapy soon after cancer diagnosis, it not suitable all patients due risk having malignant cells present fragments some types cancer. Advances 3D printing ovary-on-a-chip technologies potential be translational strategy precisely recapitulating normal terms physical structure, vascularization, molecular cellular spatial distribution. This review first introduces describes properties biomaterials engineering, highlights recent advances developing an artificial ovary. The increase survival rates young has accompanied by rise infertility/sterility survivors caused gonadotoxic effect chemotherapy regimens radiotherapy. Such side-effect negative impact on these patients' quality life one their main concerns generating biologically related children. To aid patients, several research groups resorting develop In this review, we discuss numerous cited literature that tested encapsulate vitro culture transplant isolated preantral follicles from human different animal models. We also summarize can potentially optimal